The Question Quest!

Well you know! There is a lot of questions in the world! Some with answers and some without! I want to start a quest for the ultimate question. You may say:

William Shakespeare - To be, or not to be (from Hamlet 3/1). To be, or not to be: that is the question.

Well I want a recount! And this William lived a long time ago, when to be was a lot harder than it is today. At least in my quiet little spot on this spinning rock in the great void.

I gladly take any suggestions and comments about what the question may be.